Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf

Control of Drosophila Growth and Survival by the Lipid Droplet-Associated Protein CG9186/Sturkopf

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Summary: Lipid droplets (LDs) are the universal cellular storage organelles for esterified neutral lipids.The increasing number of characterized LD-associated proteins attained LDs with hitherto unexpected functions on top of their classical role as energy depot.Here, we characterize the LD-associated protein CG9186 of Drosophila by a CRISPR/Cas9-derived mutant fly line.While the mutant flies only showed a Drawing skills at the beginning of higher education: Teachers’ perspectives, expectations, and realities mild triacylglycerol storage phenotype, they were highly protected from desiccation stress, likely linked to a reduced locomotor activity and altered cuticular hydrocarbons.

Both parameters depend on juvenile hormone (JH) signaling.Together with an observed interaction between CG9186 and JH-degrading enzymes, our results suggest that CG9186 participates in endocrine physiology regulation.In support of this hypothesis, CG9186 mutant flies show an altered expression of JH target genes and fail Música e Identidade: relatos de autobiografias musicais em pacientes com esclerose múltipla Music and identity: musical autobiographies in multiple sclerosis patients to adjust their developmental rate to dietary yeast-to-sugar ratio changes.Our results thus link LDs to organismic physiology regulation.

: Werthebach et al.introduce the lipid droplet-associated protein CG9186/sturkopf as a component of organismic physiology regulation, which affects insulin and juvenile hormone signaling activity.Keywords: lipid droplets, physiology, Drosophila, larval developmental rate, nutrient sensing, juvenile hormone, LDAH, c2orf43, desiccation, insulin signaling.